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AcmeLift
The Natural Wrinkle Care
✓ INCI
Acmella Oleracea Extract
✓ Bioactive content
60% Spilanthol by HPLC
Acmella Oleracea, often called the “toothache plant” or “jambu,” originates from the amazon region of Brazil, where it has been cultivated and valued for centuries. In traditional Brazilian culture, its leaves and flowers were used both as A culinary ingredient—famed for the tingling sensation they impart to dishes—and as A natural remedy. Indigenous communities chewed the flower heads to relieve toothaches and oral discomfort, while also applying preparations of the plant to soothe inflammation, reduce pain, and support general wellness. Today, these ethnobotanical practices form the basis for its modern recognition: in cosmetics, spilanthol extracted from Acmella Oleracea is prized as A natural wrinkle-smoothing and hydrating active, while in pharmacological research it has demonstrated promising antioxidant, anti- inflammatory, and analgesic properties. This unique bridge between traditional wisdom and modern science has established Acmella Oleracea as both A cultural heritage plant and A cutting-edge bioactive for beauty and health.
Common Names
Toothache plant, Szechuan buttons, paracress, jambu, buzz buttons, tingflowers, electric daisy
Origin
Native to tropical Brazil
Part Used
Flower
Cosmetic Benefits
Anti-Wrinkle
Spilanthol can be applied topically or subcutaneously to treat wrinkles. It works by inhibiting contractions in the facial muscles. It can be used as an alternative to Botox.
Skin Hydration
Spilanthol increases the production of hyaluronic acid, which helps the skin retain moisture. It can improve skin texture and reduce dryness.
Antioxidant & Anti-Inflammatory
Spilanthol can help protect the skin from damage caused by pollution and UV rays. It is used to reduce redness, irritation, and inflammation in the skin.
Oral Care
It is used in oral care products due to its natural analgesic properties, meaning it can provide a numbing effect, promote saliva production, and reduce gum inflammation, making it beneficial for relieving toothaches, minor mouth ulcers, and oral pain.
Potential Claims
✓ Smooths the appearance of fine lines and wrinkles,
✓ Provides an instant skin-smoothing effect
✓ Hydrates deeply for soft, supple skin
✓ Boosts natural hyaluronic acid for plumper- looking skin
✓ Calms visible redness and soothes irritation
✓ Protects against environmental stressors and oxidative damage
✓ Helps skin look firmer, refreshed, and radiant
Anti-Elastase activity
Elastase Inhibition Assay
62.5 125 250 500 1000
STD Trolox (% Inhibition) Acmella Oleracea oil 60% (% Inhibition)
✓ The results revealed that Acmella Oleracea oil 60% has high anti-elastase activity when compared to Trolox (Standard) and the percentage difference of 35.12% compared to Trolox
(Standard)
✓ The IC50 value of Acmella Oleracea oil 60% was found to be lower than Trolox, indicating that a smaller concentration of a compound is needed to achieve 50% inhibition, which means the compound is more potent.
Science backed benefits
Extensive in vitro, ex vivo, and clinical studies demonstrate the anti-aging, hydrating, antioxidant, and soothing properties of Acmella Oleracea extract.
Moisturizing Effect
Control ug/mL Hyaluronic acid
(25um/mL)
Acmella Oleracea oil 60%
(500ug/mL)
Acmella Oleracea oil 60%
(250ug/mL)
Concentration (µg/mL
✓ Results showed that the up regulation of AQP3 gene expression in 48 hrs treated cells with Acmella Oleracea oil 60% at higher concentration
500µg/mL was found to be 1.48 ± 0.11 fold
✓ Based on study using keratinocytes cells, Acmella Oleracea oil 60% has shown to significantly boost the skin’s natural hydration mechanisms
Antioxidant Capacity
Ascorbic acid Acmella Oleracea oil 60% µM equivalent to ascorbic acid
✓ The total antioxidant capacity of Acmella Oleracea oil 60% was found to be 465.333 ± 15.275 µM equivalent of ascorbic acid for the given test item
✓ Based on the study its concluded that Acmella Oleracea oil 60% exhibits antioxidant capacity
STD Trolox Acmella Oleracea Oil 60%
IC50 Value for Elastase Enzyme Inhibition
IC50 (µg/mL
IC50
Formulation Guidelines
✓ Spilanthol is lipophilic, best dissolved in: Oils (jojoba, squalane, caprylic/capric triglycerides)Silicone oils (dimethicone, cyclopentasiloxane). It can also be incorporated into emulsions (O/W or W/O) if pre-dissolved in the oil phase. Pre-dissolve Spilanthol in the oil phase for even distribution.
✓ Avoid direct addition to water-based phases unless using a solubilizer. Maintain pH 5–7 for stability and skin compatibility.
✓ Keep below 40°C during formulation to preserve activity.
✓ Store final products in opaque, airtight containers to reduce oxidation.
✓ Add antioxidants to prolong shelf life.
✓ Conduct patch testing for sensitive skin areas, especially eye or facial products.
Recommended Use Levels
Product Type Spilanthol
60% (Active) Carrier / Solvent
Serum 0.05–0.2% Squalane, Jojoba Oil, Caprylic/Capric
Triglycerides
Eye Cream 0.05–0.15% Light oils (e.g., Fractionated Coconut Oil), Dimethicone
Moisturizer / Lotion (O/W) 0.1–0.25% Oils (MCT, Jojoba) in Oil Phase
Face Mask / Ampoule 0.1–0.3% Lightweight oils or solubilized in ethanol/water mix
Facial Oil / Elixir 0.2–0.3% Carrier Oils (Squalane, Rosehip, Argan)
Further Scientific Evidence
1.Natural Oils Loaded Emulgel For Anti-microbial Action Against Dermatitis. Afzal Et Al. Gels 2023, 9, 832. Https://Doi.Org/10.3390/Gels9100832
2. Spilanthes Acmella- An Important Medicinal Plant. Sabitha Rani Et Al. International Journal Of Minor Fruits, Medicinal And Aromatic Plants. Vol. 5 (2) : 15- 26, December 2019
3. Soumya Subhashree Satapathy Et Al. Toothache Plant: A Comprehensive Review Focusing On Its Applications In Dental Health. J Herbmed Pharmacol. 2025; 14(1): 1-10.
4. Sanela M. Savic Et Al. All-natural’ Anti-wrinkle Emulsion Serum With Acmella Oleracea Extract: A Design Of Experiments (Doe) Formulation Approach, Rheology And In Vivo Skin Performance/Efficacy Evaluation. Int J
Cosmet Sci. 2021;00:1–16
5. Fathima Rabwa. Recent Discoveries On Acmella Oleracea: A Review. J Pharmacogn Nat Prod, Volume 9:2, 2023)
Antimicrobial
Proven Against Dermatitis-causing Pathogens [1]
Antifungal and Antibacterial
Activity Confirmed In Multiple Plant Parts [2]
Anti-aging
Rapid Wrinkle Parameter Improvement In
Just 2 Weeks [4]
Analgesic and Anaesthetic
Natural Oral Care Benefits {5}
Neuro-calming Effect
Supports Relaxation By Enhancing Inhibitory
Neurotransmitter (GABA) Release [3]
Concentration ug/ml
% Inhibition
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