Personal Care · Flyer
Ancient Roots in Health and Skincare
Centella Asiatica, also known as Gotu Kola, has been revered for centuries in traditional Indian and
Chinese medicine. In India, this herb has been a staple of Ayurvedic practices, where it is used to promote wound healing, improve skin elasticity, and calm inflammation. Similarly, in Chinese medicine, Centella is celebrated for its ability to cool heat, detoxify the body, and restore skin vitality.
These cultures recognized its potency long before modern skincare brought it into the spotlight.
Allergen free
GMO free
Precisely purified molecules.
Extracted from wild material with much greater active content.
Complete traceability
UEBT Nagoya Protocol
The Rise of K-Beauty and Centella’s Popularity
The global K-beauty wave has revolutionized the skincare industry, introducing innovative products that emphasize hydration, calming ingredients, and multi-step routines. Centella Asiatica, often labeled as “Cica” in these formulations, has become a cornerstone ingredient in K- beauty’s soothing skincare products. From lightweight gels to nourishing creams, these products cater to sensitive and acne-prone skin, gaining immense popularity for their gentle yet effective formulations.
Premium Products Featuring Centella Asiatica
The appeal of Centella Asiatica has translated into luxury skincare lines that are sold at premium prices globally. Brands like La Roche-Posay’s
Cicaplast Baume B5 and Dr. Jart+ Cicapair
Tiger Grass Cream are prime examples of Cica-infused products. These items, often marketed as skin-soothing and repairing solutions, highlight the herb’s effectiveness.
The Benefits of Centella Asiatica
Centella Asiatica offers many benefits, such as skin repair, anti-ageing, skin conditioning, anti-acne, skin brightening, anti-irritant, reduced inflammation, and strengthened skin barrier. For consumers, this means healthier skin and a more resilient complexion – a combination that embodies the essence of holistic skincare.
P R O D U C T S
Four bioactive blends are available. The right blend may be chosen based on desired benefits.
Genins
90.0% Total Genins (Sum of Asiatic acid &
Madecassic acid)
Asiatic Acid, Madecassic Acid
Wound healing, anti- inflammatory, antioxidant, collagen synthesis
Skin repair, soothing treatments, Anti-aging 0.1-0.5%
Asiaticoside
95% Asiaticoside
Asiaticosides Collagen synthesis, skin barrier repair
Anti-aging, scar
treatments 0.1-1.0%
Selected Terpenes (TECA)
Asiaticoside 36 – 44 %
Genins (Asiatic & Madecassic Acids) 54– 66%
Asiaticoside, Madecassic Acid, Asiatic Acid
Antioxidant, antimicrobial, brightening
Acne control, skin brightening 0.1-1.0 %
Centella Triterpenes
40% Triterpenes glycosides
Madecassoside, Asiaticoside, Madecassic Acid, Asiatic Acid Repair, hydration, anti-aging Healing balms, moisturizers 0.1-0.5%
Product INCI Benefits Applications Use levels
F E A T U R E S
The Raw Material Is Sourced Ethically From Madagascar With Following Benefits
Centellex
Repair, Renew, Restore.
Science Backed Benefits
Extensive in vitro, ex vivo, and clinical studies demonstrate the anti-aging, anti-pigmentation and hydrating properties of Centella Asiatica extract, Genins 90%.
IC50 (µg/mL % Inhibition
62.5 125 250 500 1000
Standard Genins 90%
Anti-Elastase Activity
Elastase Inhibition Assay
Elastase is an enzyme that breaks down the skin’s elastin and contributes to wrinkles and loss of firmness, so ingredients that can slow or block elastase activity help preserve skin’s elasticity and youthful appearance, making them valuable components in modern anti- aging skincare.
✓ Genins shows better Anti-elastase activity vs the standard, up to 0.1% (1000ug/mL).
✓ The IC₅₀ value of Genins was found to be much lower than control, Trolox, indicating that the ingredient is more potent (less material is needed to inhibit the elastase enzyme by 50%).
IC50 Value for Elastase Enzyme Inhibition
IC50
75.48
398.46
Genins 90% Trolox
Anti-Collagenase Activity
By inhibiting collagenase activity in cosmetic formulations, we can help preserve the skin’s collagen structure, promoting a smoother, more youthful appearance. Collagenase inhibitors are often used in anti-aging skincare products to slow down the breakdown of collagen and support the skin’s natural repair processes. This helps maintain the integrity of the skin, preventing the formation of wrinkles and improving overall skin texture.
The IC50 value for Genins 90% was found to be 183.86 ± 0.06 µg/mL, higher at up to 0.1% use levels.
0.00
20.00
40.00
60.00
80.00
100.00
62.5 125 250 500 1000
% Inhibition
Genins 90%
183.86
419.74
Genins 90% Trolox
IC50 Value for Collagenase Enzyme Inhibition
IC50
IC50 (µg/mL
Melanin Inhibition
Melanin inhibition deals with decreasing the melanogenesis process and reducing skin pigmentation.
The results show 65% and 63% of Melanin inhibition at 7.8µg/mL and 3.9µg/mL in Genins
90% treated cells, higher than Forskolin+Vit C against Forskolin-induced melanin synthesis.
Further Scientific Evidence
1Asiaticoside induces cell proliferation and collagen synthesis in human dermal fibroblasts https://univmed.org/ojs330/index.php/medicina/article/view/24/415
After 24 hours, asiaticoside at all concentrations had stronger effects on HDF proliferation than retinoic acid.1
Melanin inhibition percentage of Test items against Forskolin induced melanin synthesis in
Human Melanoma (A375) cell line.
Genins 90%-
7.8ug/mL
Genins 90%-
3.9ug/mL
Forsk+Vit C-
150ug/mL
Forsk+Vit C-
100ug/mL
Forskolin
% Melanin Inhibition
Moisturizing Effect
AQP-3 gene modulation deals with the ability to transport water and glycerol within the epidermis. This transported water is likely to plays an important role in epidermal hydration and hydrostatic pressure which maintain the skin texture by moisturizing effect.
Results showed the up regulation of AQP3 gene expression by 6.34 fold for Genins 90% in
24 hrs treated cells.
Cell Control Std-HA-250 ug/mL Genins 90%
15.62ug/ml
Genins 90%
7.8ug/ml
Relative Gene Expression (Fold)
AQP3
Formulation Guidelines
Genins are also soluble in common cosmetic preservatives such as phenoxyethanol + ethylhexylglycerin; benzyl alcohol + ethylhexylglycerin; pentylene glycol; and dimethyl Isosorbide
Standard
Solvent Genins Asiaticoside TECA Centella Triterpenes
Methanol Soluble with
Sonication Soluble with Sonication Soluble with
Sonication
Soluble with
Sonication
1,4 Dioxane Insoluble Soluble at 90°C Insoluble Insoluble
Dipropylene glycol Soluble at 90°C Soluble with Sonication Soluble at 90°C Soluble at 90°C
Propylene Glycol Soluble with
Sonication Soluble with Sonication Soluble at 90°C Soluble with
Sonication
DMSO Soluble with
Sonication Soluble with Sonication Soluble with
Sonication
Soluble with
Sonication
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